Insulin-Like Growth Factor 1 Receptor Signaling Regulates Skin Development and Inhibits Skin Keratinocyte Differentiation
نویسندگان
چکیده
منابع مشابه
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Cripto-1 is an epidermal growth factor-Cripto/FRL1/ Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cripto-1 is highly up-regulated in tumor promoter– treated normal skin and in benign papillomas. Treatment of primary mouse keratinocytes with Cript...
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Progression of B-lymphocyte development in the bone marrow of postnatal mammals is marked by progressive rearrangement and expression of immunoglobulin (Ig) heavy- and light-chain genes. Following productive VHDJH gene rearrangement in the Ig heavy-chain gene complex, mu-heavy chain is the first Ig gene product expressed in cells committed to the B-lymphoid differentiation pathway. Interleukin ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2006
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.26.7.2675-2687.2006